The Ravens will have to try to slow down Peyton Manning and the Indianapolis Colts' offense without their best pass rusher.
Terrell Suggs has been ruled out for Sunday's game with a right knee sprain. He was injured on a low hit by Cleveland quarterback Brady Quinn on an interception return Monday night.
"He's out this week, that's the ruling that we know," Baltimore coach John Harbaugh said. "It's got to heal on its own. There is no procedure that can be done. We'll just see how it goes."
Suggs declined to speak to reporters as he limped down the hallway from the locker room to the lunchroom wearing a heavy brace on his knee. When teammate Ray Rice asked Suggs how he was doing, the linebacker just shook his head.
There is a possibility that Suggs could miss between two to three weeks.
"There is no dollar amount on losing someone like (Suggs)," linebacker Ray Lewis said.
Suggs likely will be replaced by rookie second-round pick Paul Kruger, though Kruger has yet to be told by Harbaugh.
"If that's the case, I'm excited to get on the field," Kruger said.
Manning has owned the Ravens this decade like no other quarterback.
In the past six wins which spans from 2002 to last season he has completed 64 percent of his passes and averaged 246 yards passing, with 11 touchdown passes and three interceptions.
"You know he's going to be pointing and giving his fake messages," Lewis said. "We'll adjust. He'll change. We'll change. It'll go back and forth. That's why you play this game, for challenges like this. Sometimes we'll just smile at each other, like two old soldiers playing a chess match."
Lewis added, "It's intense but it's fun, too. Sometimes he gets us. Sometimes we can make him hesitate."
Besides Suggs, the other injury concern is defensive tackle Haloti Ngata, who has missed two games with an ankle injury.
"The ankle feels good," he said. "I was warming up for the game on Monday (against the Cleveland Browns), but just a few little things where I didn't feel entirely good, like changing direction quickly. But that was probably the only thing. Hopefully, we'll get that better this week, and I'll go on Sunday."
Ngata said the decision to deactivate him Monday night was precautionary. "Didn't want to aggravate the injury and make it a long-term deal."
SERIES HISTORY: 9th regular-season meeting. Colts lead series 6-2. The Ravens have lost the past six meetings with the Colts, which includes the past three at home. Indianapolis also beat Baltimore 15-6 in the 2006 playoffs en route to the Colts' Super Bowl title. The last meeting was last season, when the Colts routed the Ravens, 31-3, in Indianapolis. Peyton Manning threw three touchdowns against a Ravens defense that ranked No. 1 against the pass at the time.