Player Notes

CB D.J. Reed Jr. (strained heel, bruised chest) was injured in the Week 12 loss at Tampa Bay and already has been ruled out of the Week 13 game at Seattle.

OLB Malcolm Smith (strained Achilles) played through the pain for 26 defensive snaps in the Week 12 loss at Tampa Bay before sitting out the second half. He practiced on a limited basis Wednesday and likely will be able to play in the Week 13 game at Seattle.

G Joshua Garnett (thumb surgery) returned to practice Wednesday on a limited basis, opening the door for a possible return to game action in Week 13 against Seattle. The former first-round pick has not played since Week 10 against the New York Giants.

WR Pierre Garcon (bruised knee, strained shoulder) practiced on a limited basis on Wednesday in his quest to play for the first time since Week 9 against the Oakland Raiders. He had a similar start to his practice regimen last week before not suiting up for the loss at Tampa Bay.

WR Marquise Goodwin remained away from the team Wednesday to tend to private matters. He returned home from Florida after the team arrived on Friday and missed the Week 12 loss to the Buccaneers. 49ers head coach Kyle Shanahan said Wednesday he has no idea if his top wideout will be available for the Week 13 game at Seattle.

CB Lafayette Pitts suffered a concussion last week and he did not practice Wednesday while in the protocol.

G John Miller suffered an oblique injury and he did not practice on Wednesday.

CB Levi Wallace started his second straight game and the rookie played 96 percent of the snaps against the Jaguars. Wallace appears to have won the job opposite Tre'Davious White.

TE Charles Clay missed his second game with a hamstring injury and his status this week will most likely be questionable. He was limited in practice Wednesday.

G Vlad Ducasse has been replaced in the starting lineup by Wyatt Teller and he was inactive last week.